This is a synthetic peptide designed for use in combination with anti-RB1 Antibody(ARP58065_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Alias Symbols: OSRC, RB, pRb, pp110, p105-Rb
Protein Interaction Partner: AATF,ABL1,AR,ATF2,BDP1,BGLAP,BIRC5,BNC2,BRCA1,BRD2,BRD8,CASP10,CASP2,CASP3,CASP6,CASP7,CASP8,CASP9,CCND1,CDK2,CDK4,CDK6,CDK6,CDKN1A,CEBPD,CEBPE,DNMT1,E1A,E2F1,E2F1,E2F1,E2F1,E2F1,E2F1,E2F2,E2F2,E2F2,EID1,EID1,EPO,FRK,GNB2L1,GTF3C2,HDAC1,HDAC1,HIF1A,HMGB1,