Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
产品特性
This is a synthetic peptide designed for use in combination with anti-PSMD4 antibody (Catalog #: ARP32341_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid.
Alias Symbols: AF, ASF, S5A, AF-1, MCB1, Rpn10, pUB-R5
Protein Interaction Partner: ID1,MYOD1,NEDD8,NUB1,RAD23A,RAD23B,RAD23B,RASSF8,STUB1,TCF3,UBB,UBB,UBQLN1,UBQLN2,ADRM1,NEDD8,NUB1,PAX3,PSMD10,PSMD13,PSMD14,PSMD6,PSMD7,RAD23A,RAD23B,RASSF8,Rad23a,Rad23b,UCHL5,USP14