Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (C-Term) Peptide
PPP1R12A
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PPP1R12A products
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
- 蛋白结构域
- C-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PPP1R12A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
- 别名
- 1200015F06Rik Peptide, 5730577I22Rik Peptide, AA792106 Peptide, AV099298 Peptide, D10Ertd625e Peptide, Mypt1 Peptide, M130 Peptide, MBS Peptide, MYPT1 Peptide, M110 Peptide, MBSP Peptide, protein phosphatase 1, regulatory (inhibitor) subunit 12A Peptide, protein phosphatase 1 regulatory subunit 12A Peptide, protein phosphatase 1, regulatory subunit 12A Peptide, Ppp1r12a Peptide, PPP1R12A Peptide
- 背景
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Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.
Alias Symbols: MBS, MGC133042, MYPT1, M130
Protein Interaction Partner: DMPK,IL16,DMPK,IL16,ILK,MPRIP,PRKG1,RHOA,ROCK1,ROCK2,YWHAG,IL16,PPP1CB,PRKG1
Protein Size: 1030 - 分子量
- 113 kDa
- 基因ID
- 4659
- NCBI登录号
- NM_002480, NP_002471
- UniProt
- O14974
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