This is a synthetic peptide designed for use in combination with anti-PPARG antibody (Catalog #: ARP32879_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Alias Symbols: NR1C3, PPARG1, PPARG2, GLM1, CIMT1, PPARgamma
Protein Interaction Partner: CEP350,BRD8,CNOT1,COPS5,DNTTIP2,EDF1,FABP1,FOXO1,GADD45B,GADD45G,HDAC3,HMGA1,KIF1A,MAPK1,MAPK8,MED1,MED24,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NFE2L2,NR0B1,NR0B2,NRIP1,PPARG,PPARGC1A,PRIC285,RANBP9,RXRA,RXRB,RXRG,SMARCD3,SYT1,BCAS2,CREBBP,DNTTIP2,EDF1,EP300,FABP1,GADD45G,Gadd45b,HDAC3,HDAC4,MED1,MED24,MPG,NCOA2,NCOA3,NCOA4,NFE2L2,NR0B2,NRIP1,POU1F1,PPARGC1A,PRMT2,RB1,RXRA,SVIL