This is a synthetic peptide designed for use in combination with anti-PIN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: DOD, UBL5
Protein Interaction Partner: CCND1,CDC27,PKMYT1,PLK1,RAF1,TP73,TP73,APP,BCL2,CCNB1,CCNE1,CDC25C,CDC27,CDK1,CDK9,CHPF,CSNK2A1,CSNK2A2,CSNK2B,CTNNB1,DAB2,DDX24,FASLG,GGA2,GPAA1,GPHN,JUN,KIF20B,KLHL20,LEPR,MAPT,MDFI,MTFR1,NCOA3,NEK6,NFATC2,NONO,PKMYT1,PLK1,POLR2A,PTOV1,PTPN1,RAB4A,RAF1,