Nuclear Prelamin A Recognition Factor (NARF) (Middle Region) Peptide
NARF
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all NARF products
- NARF (Nuclear Prelamin A Recognition Factor (NARF))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- RGQAQTPDGH ADKALLRQME GIYADIPVRR PESSAHVQEL YQEWLEGINS
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-NARF Antibody(ARP54491_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- NARF (Nuclear Prelamin A Recognition Factor (NARF))
- 背景
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Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. NARF binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. NARF is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases.
Alias Symbols: DKFZp434G0420, FLJ10067, IOP2
Protein Interaction Partner: LMNA,LMNA
Protein Size: 397 - 分子量
- 45 kDa
- 基因ID
- 26502
- NCBI登录号
- NM_001038618, NP_001033707
- UniProt
- B3KPX2
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