GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptide
GAPVD1
适用: 人
宿主: 合成
BP, IHC, WB
-
- 抗原 See all GAPVD1 products
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-GAPVD1 antibody (Catalog #: ARP42451_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
- 别名
- zgc:92666 Peptide, GAPEX5 Peptide, RAP6 Peptide, 2010005B09Rik Peptide, 4432404J10Rik Peptide, AW108497 Peptide, Gapex-5 Peptide, RME-6 Peptide, mKIAA1521 Peptide, RGD1307479 Peptide, GTPase activating protein and VPS9 domains 1 Peptide, GTPase activating protein and VPS9 domains 1 S homeolog Peptide, LOAG_00609 Peptide, GAPVD1 Peptide, gapvd1 Peptide, gapvd1.S Peptide, Gapvd1 Peptide
- 背景
-
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
Protein Interaction Partner: YWHAB,CBL
Protein Size: 1487 - 分子量
- 166 kDa
- 基因ID
- 26130
- NCBI登录号
- NM_015635, NP_056450
-
You are here:
