This is a synthetic peptide designed for use in combination with anti-FOXO4 antibody (Catalog #: AVARP01018_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
FOXO4 is transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The protein can down-regulate expression of HIF1A and suppress hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias.
Alias Symbols: AFX, AFX1, MGC120490, MLLT7
Protein Interaction Partner: AKT1,CCND1,CDKN1A,CTNNB1,FOXG1,SMAD3,SMAD4,AKT1,AKT2,CREBBP,CTNNB1,ESR1,FOXG1,SMAD3,SMAD4,XPO1,YWHAZ,CREBBP,ESR1,MDM2,PIN1,SMAD3,SMAD4,UBC,USP7,XPO1