CDC25A
(Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
蛋白结构域
Middle Region
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
产品特性
This is a synthetic peptide designed for use in combination with anti-CDC25A antibody (Catalog #: AVARP03040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CDC25A2
Protein Interaction Partner: E2F1,E2F2,E2F3,E2F4,CHEK1,CHEK1,AR,BTRC,CCNA1,CCNB1,CCNE1,CDK1,CDK2,CDKN3,CHEK1,CHEK2,CUX1,EGFR,FBXW11,HRAS,MAP3K5,NAA10,PIM1,RAF1,ROCK1,SMAD3,UBB,YWHAB,YWHAE,YWHAZ,BTRC,CCNA1,CCNB1,CCNE1,CDK2,CHEK1,CHEK2,EGFR,MAP3K5,MAPK14,NAA10,PIM1,RAF1,ROCK1,UBC,YWHAB,YWHAB,YWHAE,YWHAE,YWHAZ