A synthetic peptide for use as a blocking control in assays to test for specificity of CRYAB antibody, Alternative Names: Crystallin Alpha B control peptide, Crystallin Alpha B antibody Blocking Peptide, Anti-Crystallin Alpha B Blocking Peptide, CRYAB Blocking Peptide, CRYA2 Blocking Peptide, CTPP2 Blocking Peptide, HSPB5 Blocking Peptide
Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.