A synthetic peptide for use as a blocking control in assays to test for specificity of PYHIN1 antibody, Alternative Names: PYHIN1 control peptide, PYHIN1 antibody Blocking Peptide, Anti-PYHIN1 Blocking Peptide, pyrin and HIN domain family, member 1 Blocking Peptide, IFIX Blocking Peptide, MGC23885 Blocking Peptide, RP11-520H16.1 Blocking Peptide, PYHIN1, PYHIN-1, PYHIN 1, PYHIN-1 Blocking Peptide, PYHIN 1 Blocking Peptide
Optimal conditions should be determined by the investigator
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
缓冲液
PBS
注意事项
Avoid repeated freeze/thaw cycles.
储存条件
-20 °C
储存方法
Store at -20 °C long term.
抗原
PYHIN1
(Pyrin and HIN Domain Family, Member 1 (PYHIN1))
别名
IFIX Peptide, RP11-520H16.1 Peptide, 4930422C14 Peptide, AI447904 Peptide, Ifi209 Peptide, Ifix Peptide, pyrin and HIN domain family member 1 Peptide, interferon activated gene 209 Peptide, PYHIN1 Peptide, Ifi209 Peptide
背景
PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.