A synthetic peptide for use as a blocking control in assays to test for specificity of HARS antibody, Alternative Names: HARS control peptide, HARS antibody Blocking Peptide, Anti-HARS Blocking Peptide, histidyl-tRNA synthetase Blocking Peptide, FLJ20491 Blocking Peptide, HRS Blocking Peptide
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.