A synthetic peptide for use as a blocking control in assays to test for specificity of TBK1 antibody, Alternative Names: TBK1 control peptide, TBK1 antibody Blocking Peptide, Anti-TBK1 Blocking Peptide, Tank-Binding Kinase 1 Blocking Peptide, FLJ11330 Blocking Peptide, NAK Blocking Peptide, T2K Blocking Peptide, TBK1, TBK-1, TBK 1, TBK-1 Blocking Peptide, TBK 1 Blocking Peptide
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TBK1 is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.