A synthetic peptide for use as a blocking control in assays to test for specificity of RUNX2 antibody, Alternative Names: RUNX2 control peptide, RUNX2 antibody Blocking Peptide, Anti-RUNX2 Blocking Peptide, Runt-Related Transcription Factor 2 Blocking Peptide, RUNX2, RUNX-2, RUNX 2, RUNX-2 Blocking Peptide, RUNX 2 Blocking Peptide
RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.