A synthetic peptide for use as a blocking control in assays to test for specificity of BPNT1 antibody, Alternative Names: BPNT1 control peptide, BPNT1 antibody Blocking Peptide, Anti-BPNT1 Blocking Peptide, 3' 2' 5'-bisphosphate nucleotidase 1 Blocking Peptide, 2', 5'-Bisphosphate Nucleotidase 1 Blocking Peptide, PIP Blocking Peptide, BPNT1, BPNT-1, BPNT 1, BPNT-1 Blocking Peptide, BPNT 1 Blocking Peptide
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92 % identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.