A synthetic peptide for use as a blocking control in assays to test for specificity of OAZ3 antibody, Alternative Names: OAZ3 control peptide, OAZ3 antibody Blocking Peptide, Anti-OAZ3 Blocking Peptide, ornithine decarboxylase antizyme 3 Blocking Peptide, AZ3 Blocking Peptide, OAZ-t Blocking Peptide, TISP15 Blocking Peptide, OAZ3, OAZ-3, OAZ 3, OAZ-3 Blocking Peptide, OAZ 3 Blocking Peptide
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.