A synthetic peptide for use as a blocking control in assays to test for specificity of IL1 B antibody, Alternative Names: IL1 beta control peptide, IL1 beta antibody Blocking Peptide, Anti-IL1 beta Blocking Peptide, Interleukin 1 Beta Blocking Peptide, IL-1 Blocking Peptide, IL1-BETA Blocking Peptide, IL1F2 Blocking Peptide, IL1B Blocking Peptide, IL1 beta, IL beta-1, IL beta 1, IL beta-1 Blocking Peptide, IL beta 1 Blocking Peptide
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.