Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) (Middle Region) Peptide
GP1BB
适用: 人
宿主: 合成
WB, BP
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- 抗原 See all GP1BB products
- GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Western Blotting (WB), Blocking Peptide (BP)
- 序列
- ALRTAHLGAN PWRCDCRLVP LRAWLAGRPE RAPYRDLRCV APPALRGRLL
- 产品特性
- This is a synthetic peptide designed for use in combination with anti- GP1BB Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) peptide
GP1BB 适用: 大鼠 宿主: 大肠杆菌（E. Coli） WB, ELISA, IP, SDS Dithiothreitol (DTT)
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
- 别名
- BDPLT1 Peptide, BS Peptide, CD42C Peptide, GPIBB Peptide, glycoprotein Ib (platelet), beta polypeptide Peptide, glycoprotein Ib platelet beta subunit Peptide, glycoprotein Ib, beta polypeptide Peptide, GP1BB Peptide, Gp1bb Peptide
- 背景
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Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
Alias Symbols: BS, CD42C, GPIBB, BDPLT1, GPIbbeta
Protein Size: 206 - 基因ID
- 2812
- NCBI登录号
- NM_000407, NP_000398
- UniProt
- P13224
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