This is a synthetic peptide designed for use in combination with anti- FADD Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
储存条件
-20 °C
储存方法
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
抗原
FADD
(Fas (TNFRSF6)-Associated Via Death Domain (FADD))
别名
MORT1 Peptide, Mort1/FADD Peptide, Mort1 Peptide, TNFRSF6 Peptide, adaptor Peptide, fadd Peptide, mort1 Peptide, xfadd Peptide, Fas associated via death domain Peptide, Fas (TNFRSF6)-associated via death domain Peptide, Fas associated via death domain S homeolog Peptide, Fas (tnfrsf6)-associated via death domain Peptide, FADD Peptide, Fadd Peptide, fadd.S Peptide, fadd Peptide
背景
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.