Retinoblastoma 1 (RB1) (Middle Region) Peptide
RB1
适用: 人, 小鼠
宿主: 合成
BP, WB
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- 抗原 See all Retinoblastoma 1 (RB1) products
- Retinoblastoma 1 (RB1)
- 蛋白结构域
- Middle Region
- 宿主
- 人, 小鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- TETQAASAFH TQKPLKSTSL ALFYKKVYRL AYLRLNTLCA RLLSDHPELE
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Rb1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- Retinoblastoma 1 (RB1)
- 别名
- OSRC Peptide, RB Peptide, p105-Rb Peptide, pRb Peptide, pp110 Peptide, Rb Peptide, Rb-1 Peptide, P105-RB Peptide, PP110 Peptide, RB11 Peptide, zgc:154147 Peptide, RB transcriptional corepressor 1 Peptide, RB transcriptional corepressor like 1 Peptide, retinoblastoma 1 Peptide, RB1 Peptide, RBL1 Peptide, Rb1 Peptide, rb1 Peptide
- 背景
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SLC11A1 is key regulator of entry into cell division that acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex By similarity.
Alias Symbols: Rb, Rb-1, pRb
Protein Size: 921 - 分子量
- 101 kDa
- 基因ID
- 19645
- NCBI登录号
- NM_009029, NP_033055
- UniProt
- P13405
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