PEX5 产品
(Peroxisomal Biogenesis Factor 5 (PEX5))
Categories
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
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Featured PEX5 Categories
Recommended PEX5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6145469
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7261734
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IF, FACS
Validations
- (4)
Cat. No.
ABIN1500156
Quantity
100 μL
Datasheet
Datasheet
Recommended PEX5 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6233831
Quantity
96 tests
Datasheet
Datasheet
Recommended PEX5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124372
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314707
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131369
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PEX5 Products
: "Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity." in: Journal of lipid research, Vol. 57, Issue 7, pp. 1133-43, (2016) (PubMed).: "A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS." in: Nature cell biology, Vol. 15, Issue 10, pp. 1186-96, (2013) (PubMed).
: "Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27243-51, (2009) (PubMed).
: "Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse)." in: The American journal of pathology, Vol. 159, Issue 4, pp. 1477-94, (2001) (PubMed).
: "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import." in: The Journal of cell biology, Vol. 147, Issue 4, pp. 761-74, (1999) (PubMed).
: "Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5666-73, (1999) (PubMed).
: "A mouse model for Zellweger syndrome." in: Nature genetics, Vol. 17, Issue 1, pp. 49-57, (1997) (PubMed).
Synonyms and alternative names related to PEX5
peroxisomal biogenesis factor 5 (pex5), peroxisomal biogenesis factor 5 (Pex5), peroxisomal biogenesis factor 5 (PEX5), AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, Pxr1, PXR1, X83306Protein level used designations for PEX5
- peroxisome biogenesis factor 5
- PTS1 receptor
- PTS1-BP
- PXR1P
- peroxin 5
- peroxisomal C-terminal targeting signal import receptor
- peroxisomal targeting signal 1 receptor
- peroxisome receptor 1
- peroxin-5
- peroxisomal targeting signal 1 (SKL type) receptor
- peroxisomal targeting signal import receptor
- peroxisomal targeting signal receptor 1
- PTS1R
- Peroxisomal C-terminal targeting signal import receptor
- Peroxisome receptor 1
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