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PDHX 蛋白

(Pyruvate Dehydrogenase Complex, Component X (PDHX))

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

recommended

PDHX Protein (AA 1-109) (GST tag) (ABIN1314527)

PDHX 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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recommended

PDHX Protein (AA 54-501) (His tag) (ABIN7124721)

PDHX 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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recommended

PDHX Protein (AA 220-468) (His tag) (ABIN7416460)

PDHX 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, Imm, PC

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PDHX 蛋白 by Origin

Find PDHX 蛋白 for a variety of species such as anti-Human PDHX, anti-Cow PDHX, anti-Mouse PDHX. The species listed below are among those available. Click on a link to go to the corresponding products.

PDHX 蛋白 by Source

Here you will find PDHX 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PDHX 蛋白 by 蛋白类型

Here you can find PDHX 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

PDHX 蛋白 by 应用范围

Find PDHX 蛋白 validated for a specific application such as WB, ELISA, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular PDHX 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

PDHX Protein (AA 1-109) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1314527

Quantity 10 μg

Datasheet Datasheet

PDHX Protein (AA 54-501) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124721

Quantity 50 μg

Datasheet Datasheet

PDHX Protein (AA 220-468) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7416460

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (AA 222-471) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7416508

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (AA 54-500) (His tag)

Reactivity Pig

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7424446

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2728549

Quantity 20 μg

Datasheet Datasheet

PDHX Protein (AA 54-501) (His tag)

Reactivity Cow

Source Yeast

Validations

Cat. No. ABIN1459716

Quantity 1 mg

Datasheet Datasheet

Aliases for PDHX 蛋白

pyruvate dehydrogenase complex component X (PDHX) 蛋白
pyruvate dehydrogenase complex, component X (Pdhx) 蛋白
pyruvate dehydrogenase complex, component X (pdhx) 蛋白
pyruvate dehydrogenase complex component X L homeolog (pdhx.L) 蛋白
E3-binding protein (pdhX) 蛋白
pyruvate dehydrogenase complex component X (pdhx) 蛋白
Ac1164 蛋白
AI481367 蛋白
DDBDRAFT_0168431 蛋白
DDBDRAFT_0230192 蛋白
DDB_0168431 蛋白
DDB_0230192 蛋白
DLDBP 蛋白
E3BP 蛋白
E3bp 蛋白
MGC86218 蛋白
OPDX 蛋白
PDHX 蛋白
PDX1 蛋白
Pdx1 蛋白
proX 蛋白
zgc:66110 蛋白
zgc:85977 蛋白

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PDHX 蛋白 by Origin

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PDHX 蛋白 by 蛋白类型

PDHX 蛋白 by 应用范围

Popular PDHX 蛋白

Aliases for PDHX 蛋白

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