PDE4B 产品
(phosphodiesterase 4B, cAMP-Specific (PDE4B))
Categories
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured PDE4B Categories
PDE4B 抗体
High quality antibodies with extensive validation data.
PDE4B ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PDE4B 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDE4B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7442141
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN185574
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
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- (2)
Cat. No.
ABIN7146632
Quantity
100 μg
Datasheet
Datasheet
Recommended PDE4B ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969261
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
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- (1)
Cat. No.
ABIN6958532
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5657767
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE4B 蛋白
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Reactivity
Source
Validations
Cat. No.
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Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7414258
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094409
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2728515
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PDE4B Products
: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).
: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).
: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
Synonyms and alternative names related to PDE4B
phosphodiesterase 4B (pde4b), phosphodiesterase 4B (PDE4B), phosphodiesterase 4B, cAMP specific (Pde4b), phosphodiesterase 4B (Pde4b), phosphodiesterase 4B S homeolog (pde4b.S), dpde4, Dpde4, DPDE4, dunce, PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, pde4b5, PDE4B5, pdeivb, PDEIVB, R74983Protein level used designations for PDE4B
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog)
- phosphodiesterase 4B, cAMP-specific
- phosphodiesterase 4B
- 3',5'-cyclic AMP phosphodiesterase
- DPDE4
- Phosphodiesterase 4B cAMP-specific (dunce
- Phosphodiesterase 4B, cAMP-specific (dunce
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B
- PDE32
- cAMP-specific phosphodiesterase-4 B isoform
- dunce-like phosphodiesterase E4
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
- phosphodiesterase 4B, cAMP specific
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