PDE4A 产品
(phosphodiesterase 4A, CAMP-Specific (PDE4A))
Categories
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
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Featured PDE4A Categories
Recommended PDE4A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, FACS, IHC (p)
Validations
- (7)
Cat. No.
ABIN1500089
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7243706
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7269302
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE4A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231741
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE4A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314462
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2728507
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094538
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE4A Products
: "CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. ..." in: PLoS biology, Vol. 16, Issue 6, pp. e2004408, (2018) (PubMed).: "The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells." in: Mediators of inflammation, Vol. 2016, pp. 3745961, (2017) (PubMed).
: "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis." in: The Journal of pathology, Vol. 240, Issue 1, pp. 96-107, (2017) (PubMed).
: "Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer." in: Cell death & disease, Vol. 7, pp. e2211, (2016) (PubMed).
: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).
: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).
: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).
: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).
: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).
Synonyms and alternative names related to PDE4A
phosphodiesterase 4A S homeolog (pde4a.S), phosphodiesterase 4A, cAMP-specific (pde4a), phosphodiesterase 4A (PDE4A), phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (LOC100009247), phosphodiesterase 4A (Pde4a), phosphodiesterase 4A (pde4a), phosphodiesterase 4A, cAMP specific (Pde4a), phosphodiesterase 4C (PDE4C), phosphodiesterase 4A, cAMP-specific (PDE4A), D9Ertd60e, dpde2, Dpde2, DPDE2, pde4, PDE4, PDE4A, Pde4a, pde46, PDE46, PHOSAProtein level used designations for PDE4A
- phosphodiesterase 4A, cAMP-specific
- phosphodiesterase 4A-like
- phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
- cyclic AMP-specific phosphodiesterase FCPDE4A1A
- cyclic AMP-specific phosphodiesterase OCPDE4A1A
- phosphodiesterase 4A, cAMP specific
- cyclic AMP-specific phosphodiesterase CPPDE4A1A
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A
- cAMP-specific phosphodiesterase PDE4A
- cyclic AMP specific phosphodiesterase PDE4A5A
- dunce
- phosphodiesterase 4A, cAMP-specific (dunce
- phosphodiesterase E2 dunce homolog, Drosophila
- phosphodiesterase isozyme 4
- DPDE2
- cyclic AMP-specific phosphodiesterase SSPDE4A1A
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