PDE1B 产品
(phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))
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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
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Featured PDE1B Categories
Recommended PDE1B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (1)
- (6)
Cat. No.
ABIN1724781
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (1)
- (7)
Cat. No.
ABIN1724782
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (1)
- (5)
Cat. No.
ABIN1724783
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE1B 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314453
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
Cat. No.
ABIN7317495
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3085911
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE1B Products
: "Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways." in: Cell reports, Vol. 15, Issue 7, pp. 1430-41, (2016) (PubMed).: "Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles." in: Reproduction (Cambridge, England), Vol. 150, Issue 1, pp. 11-20, (2016) (PubMed).
: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." in: Biochimica et biophysica acta, Vol. 1842, Issue 7, pp. 916-26, (2014) (PubMed).
: "Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." in: Molecular nutrition & food research, Vol. 55, Issue 11, pp. 1677-89, (2012) (PubMed).
: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).
: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).
: "Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells." in: Molecular immunology, Vol. 47, Issue 4, pp. 678-84, (2010) (PubMed).
: "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." in: Biochemical pharmacology, Vol. 79, Issue 3, pp. 321-9, (2009) (PubMed).
: "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum." in: Neuropharmacology, Vol. 54, Issue 4, pp. 745-54, (2008) (PubMed).
Synonyms and alternative names related to PDE1B
phosphodiesterase 1B, Ca2+-calmodulin dependent (Pde1b), phosphodiesterase 1B (PDE1B), phosphodiesterase 1B (Pde1b), 63kDa, Aop2, Pde1b1, PDE1B1, PDES1BProtein level used designations for PDE1B
- 63 kDa Cam-PDE
- calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
- cam-PDE 1B
- phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa
- phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
- calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
- calmodulin-stimulated phosphodiesterase PDE1B1
- presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
- anti-oxidant protein 2
- cyclic nucleotide phosphodiesterase (CaM-PDE)
- phosphodiesterase 1B, Ca2+calmodulin dependent
- phosphodiesterase 1B1 Ca2+-calmodulin dependent 63 kDa
- phosphodiesterase IB calmodulin-dependent
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