PDE11A 产品
(phosphodiesterase 11A (PDE11A))
Categories
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PDE11A Categories
Recommended PDE11A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7150681
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)
Application
IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN213553
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN195735
Quantity
100 μg
Datasheet
Datasheet
Recommended PDE11A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094408
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3132723
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2728475
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PDE11A Products
: "Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?" in: Current pharmaceutical design, Vol. 21, Issue 3, pp. 389-416, (2015) (PubMed).: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." in: Cellular signalling, Vol. 26, Issue 2, pp. 383-97, (2014) (PubMed).
: "Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer." in: World journal of urology, Vol. 31, Issue 2, pp. 325-30, (2013) (PubMed).
: "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." in: International journal of impotence research, Vol. 23, Issue 5, pp. 206-12, (2012) (PubMed).
: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).
: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).
: "Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 5, pp. 687-94, (2009) (PubMed).
: "PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system." in: Brain research, Vol. 1281, pp. 25-34, (2009) (PubMed).
: "Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate." in: European urology, Vol. 49, Issue 4, pp. 740-5, (2007) (PubMed).
Synonyms and alternative names related to PDE11A
phosphodiesterase 11A (PDE11A), phosphodiesterase 11A (Pde11a), phosphodiesterase 11a (pde11a), phosphodiesterase 11A (pde11a), dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (LOC100470038), dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Pde11a), 6330414F14Rik, A630086N24Rik, Gm350, PDE11A, Pde11a, PDE11A1, PPNAD2, ppnad2, si:ch211-222f23.5Protein level used designations for PDE11A
- cAMP and cGMP cyclic nucleotide phosphodiesterase 11A
- dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
- cAMP and cGMP phosphodiesterase 11A
- phosphodiesterase 11A
- dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like
- phosphodiesterase 11a
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