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PCDHGB2 产品

(Protocadherin gamma Subfamily B, 2 (PCDHGB2))
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].

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Featured PCDHGB2 Categories

PCDHGB2 抗体

High quality antibodies with extensive validation data.

PCDHGB2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

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Latest Publications for our PCDHGB2 Products

Lobas, Helsper, Vernon, Schreiner, Zhang, Holtzman, Thedens, Weiner: "Molecular heterogeneity in the choroid plexus epithelium: the 22-member ?-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation." in: Journal of neurochemistry, Vol. 120, Issue 6, pp. 913-27, (2012) (PubMed).

Prasad, Weiner: "Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the ?-Protocadherins." in: Frontiers in molecular neuroscience, Vol. 4, pp. 54, (2012) (PubMed).

Synonyms and alternative names related to PCDHGB2

protocadherin gamma subfamily B, 2 (PCDHGB2), protocadherin gamma subfamily B, 2 (Pcdhgb2), PCDH-GAMMA-B2

Protein level used designations for PCDHGB2

  • protocadherin gamma-B2
  • 3' RACE product
  • protocadherin gamma B2
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