PCDHGA3 产品
(Protocadherin gamma A3 (PCDHgA3))
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This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
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Latest Publications for our PCDHGA3 Products
: "Protocadherin γ A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4622-4628, (2017) (PubMed).Synonyms and alternative names related to PCDHGA3
protocadherin gamma subfamily A, 3 (PCDHGA3), protocadherin gamma subfamily A, 3 (Pcdhga3), PCDH-GAMMA-A3Protein level used designations for PCDHGA3
- protocadherin gamma-A3
- PCDH-gamma-A3
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