PCDHG 抗体 (C-Term, Cytoplasmic Domain, pan)
PCDHG
适用: 小鼠, 大鼠
ICC, IF, WB
宿主: 小鼠
Monoclonal
S159-5
unconjugated
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- 抗原
- PCDHG (Protocadherin gamma Cluster (PCDHG))
- 抗原表位
- AA 808-931, C-Term, Cytoplasmic Domain, pan
- 适用
- 小鼠, 大鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
- 特异性
- This antibody detects a ~100 kDa protein. Cross-reacts with all Gamma- protocadherin-A, -B and -C proteins. Species: Mouse and Rat.
- 纯化方法
- Protein G Chromatography
- 免疫原
- Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A-subfamily: amino acids ~807-930, B-subfamily: amino acids ~789-912 and C subfamily).
- 克隆位点
- S159-5
- 亚型
- IgG1
-
- 应用备注
- Western blot: 1/1000, 1 μg/mL was sufficient for detection of PCDHG (pan) in 20 μg of Rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody. Immunocytochemistry .
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS pH 7.4, 50 % Glycerol, 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
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- 抗原
- PCDHG (Protocadherin gamma Cluster (PCDHG))
- 别名
- pcdhg
- 背景
- The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
- 基因ID
- 93709
- UniProt
- Q91XZ0
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