CD4 FITC - CD28 PE Bi-Test Reagent
FACS
适用: 人
FACS
FITC,PE
宿主: 小鼠
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- 抗原
- CD4 + CD28
- 适用
- 人
- 宿主
- 小鼠
- 标记
- FITC,PE
- 应用范围
- Flow Cytometry (FACS)
- 品牌
- Bi-Test™
- 纯化方法
- Protein A/G Chromatography
- 亚型
- IgG1
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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- 抗原
- CD4 + CD28
- 别名
- CD4, CD28
- 背景
- Identification of CD4 on human helper/inducer T cells expressing the 60,000 M.W. surface antigen (HLA class II reactive). CD4 is present in low density on monocytes. Anti-human CD28 binds the 44 kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 Molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60 % -80 % of lymphocytes (95 % of CD4 and 50 % of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
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