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p63 产品

(Tumor Protein P63 (TP63))
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].

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Featured p63 Categories

p63 抗体

High quality antibodies with extensive validation data.

p63 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

p63 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended p63 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ICC, IP, IF, IHC (p), IHC (fro), PLA
Validations
  • (8)
  • (8)
Cat. No. ABIN2855394
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (5)
Cat. No. ABIN3023012
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, Coat
Validations
  • (4)
Cat. No. ABIN6940965
Quantity 100 μg
Datasheet Datasheet

Recommended p63 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971006
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960310
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960311
Quantity 96 tests
Datasheet Datasheet

Recommended p63 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1323400
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125563
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323402
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our p63 Products

Kim, Dollé, Vermeij, Gyenis, Vogel, Hoeijmakers, Wiley, Davalos, Hasty, Desprez, Campisi: "Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin." in: Aging cell, Vol. 19, Issue 3, pp. e13072, (2020) (PubMed).

Li, Wang, Torkelson, Shankar, Pattison, Zhen, Fang, Duren, Xin, Gaddam, Melo, Piekos, Li, Liaw, Chen, Li, Wernig, Wong, Chang, Oro: "TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment." in: Cell stem cell, Vol. 24, Issue 2, pp. 271-284.e8, (2020) (PubMed).

Jiang, Zhu, He, Gao, Tian, Ma, Wu, Das, Severinov, Hitzeroth, Debata, Liu, Zou, Shi, Xu, Wang, Bao, Ka-Kit, You, Cui, Hu: "Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women." in: Translational oncology, Vol. 12, Issue 7, pp. 959-967, (2019) (PubMed).

Montoro, Haber, Biton, Vinarsky, Lin, Birket, Yuan, Chen, Leung, Villoria, Rogel, Burgin, Tsankov, Waghray, Slyper, Waldman, Nguyen, Dionne, Rozenblatt-Rosen, Tata, Mou, Shivaraju, Bihler, Mense et al.: "A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. ..." in: Nature, Vol. 560, Issue 7718, pp. 319-324, (2019) (PubMed).

Xiong, Ren, Chen, Liu, Huang, Zhang, Odera, Chen, Kist, Peters, Garman, Sun, Chen: "PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium." in: The Journal of pathology, Vol. 244, Issue 2, pp. 164-175, (2019) (PubMed).

OBrien, Dorsey, Hannan, Hultgren: "Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner." in: PLoS pathogens, Vol. 14, Issue 12, pp. e1007457, (2019) (PubMed).

Tata, Kobayashi, Chow, Tran, Desai, Massri, McCord, Gunn, Tata: "Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury." in: Cell stem cell, Vol. 22, Issue 5, pp. 668-683.e6, (2018) (PubMed).

Reneker, Wang, Irlmeier, Huang: "Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse." in: Investigative ophthalmology & visual science, Vol. 58, Issue 5, pp. 2638-2646, (2017) (PubMed).

OBrien, Hannan, Yu, Livny, Roberson, Schwartz, Souza, Mendelsohn, Colonna, Lewis, Hultgren: "A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease." in: Nature microbiology, Vol. 2, pp. 16196, (2016) (PubMed).

Zhang, Wei, Dang, Xie, Zhong, Ma, Chen: "Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report." in: International journal of clinical and experimental pathology, Vol. 7, Issue 12, pp. 9032-7, (2015) (PubMed).

Synonyms and alternative names related to p63

tumor protein p63 (TP63), tumor protein p63 (tp63), tumor protein p63 (Tp63), transformation related protein 63 (Trp63), tumor protein p63 L homeolog (tp63.L), AI462811, AIS, B(p51A), B(p51B), DNp63, EEC3, id:ibd3516, KET, Ket, ket, LMS, NBP, np63, OFC8, p40, p51, P51/P63, p53CP, p63, P63, p73H, p73L, P73l, RHS, SHFM4, TP53CP, TP53L, TP63, tp63, Tp63, TP73L, tp73l, Tp73l, tp73l-A, Trp53rp1, Trp63, TRP63, trp63, wu:fc89f04, wu:fk85h07, wu:fk88b02, Xp63

Protein level used designations for p63

  • CUSP
  • amplified in squamous cell carcinoma
  • chronic ulcerative stomatitis protein
  • keratinocyte transcription factor KET
  • transformation-related protein 63
  • tumor protein 63
  • tumor protein p53-competing protein
  • tumor protein p63 deltaN isoform delta
  • tumor protein p63
  • delta-Np63
  • fc89f04
  • transformation related protein 63
  • tumor protein 63 kDa
  • tumor protein 63-like
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