P5CS 产品
(Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))
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This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured P5CS Categories
P5CS 抗体
High quality antibodies with extensive validation data.
P5CS ELISA试剂盒
Reliable ELISA kits for a wide range of species.
P5CS 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended P5CS 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
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- (3)
Cat. No.
ABIN519568
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
Cat. No.
ABIN652885
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN562547
Quantity
50 μL
Datasheet
Datasheet
Recommended P5CS ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN770580
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN778158
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN774259
Quantity
96 tests
Datasheet
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Recommended P5CS 蛋白
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344810
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344809
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
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ABIN3085588
Quantity
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Datasheet
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Latest Publications for our P5CS Products
: "Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway." in: Molecular cancer research : MCR, Vol. 13, Issue 10, pp. 1408-20, (2016) (PubMed).: "Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1." in: Molecular genetics and metabolism, Vol. 112, Issue 4, pp. 310-6, (2014) (PubMed).
: "Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress." in: Journal of proteome research, Vol. 13, Issue 10, pp. 4398-423, (2014) (PubMed).
: "Functional specialization in proline biosynthesis of melanoma." in: PLoS ONE, Vol. 7, Issue 9, pp. e45190, (2012) (PubMed).
: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).
: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, (2010) (PubMed).
: "Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 2, pp. 474-485 (PubMed).
Synonyms and alternative names related to P5CS
aldehyde dehydrogenase 18 family member A1 (ALDH18A1), aldehyde dehydrogenase 18 family member A1 (aldh18a1), aldehyde dehydrogenase 18 family, member A1 (ALDH18A1), aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), aldehyde dehydrogenase 18 family, member A1 (aldh18a1), aldehyde dehydrogenase 18 family member A1 L homeolog (aldh18a1.L), aldehyde dehydrogenase 18 family member A1 (Aldh18a1), 2810433K04Rik, AI429789, ALDH18A1, ARCL3A, cb842, cb899, GSAS, P5CS, PYCS, Pycs, pycs, sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12Protein level used designations for P5CS
- pyrroline-5-carboxylate synthetase
- aldehyde dehydrogenase 18 family, member A1
- Delta-1-pyrroline-5-carboxylate synthetase
- P5CS
- aldehyde dehydrogenase 18A1
- aldehyde dehydrogenase family 18 member A1
- delta-1-pyrroline-5-carboxylate synthase
- aldehyde dehydrogenase 18A1-like
- delta-1-pyrroline-5-carboxylate synthetase
- delta1-pyrroline-5-carboxlate synthetase
- pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
- glutamate gamma-semialdehyde synthetase
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