p300 产品
(E1A Binding Protein P300 (EP300))
Categories
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].
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Featured p300 Categories
p300 抗体
High quality antibodies with extensive validation data.
p300 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
p300 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended p300 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (6)
Cat. No.
ABIN6140193
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (1)
- (4)
Cat. No.
ABIN560748
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (6)
Cat. No.
ABIN3042372
Quantity
100 μg
Datasheet
Datasheet
Recommended p300 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955487
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955486
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955488
Quantity
96 tests
Datasheet
Datasheet
Recommended p300 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352865
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2669637
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (1)
- (1)
Cat. No.
ABIN2720219
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our p300 Products
: "Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions." in: Molecular cell, Vol. 71, Issue 5, pp. 718-732.e9, (2019) (PubMed).: "MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes." in: Molecular cell, Vol. 70, Issue 5, pp. 825-841.e6, (2018) (PubMed).
: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).
: "miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy." in: Diabetes, Vol. 65, Issue 3, pp. 768-79, (2016) (PubMed).
: "Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions." in: Scientific reports, Vol. 6, pp. 29311, (2016) (PubMed).
: "PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia." in: Oncotarget, Vol. 7, Issue 6, pp. 6379-97, (2016) (PubMed).
: "An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility." in: Biological psychiatry, Vol. 80, Issue 12, pp. 943-954, (2016) (PubMed).
: "A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer." in: Oncotarget, Vol. 7, Issue 6, pp. 7253-67, (2016) (PubMed).
: "The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway." in: Biochemical pharmacology, Vol. 101, pp. 100-11, (2016) (PubMed).
: "Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120352, (2015) (PubMed).
Synonyms and alternative names related to p300
E1A binding protein p300 (EP300), histone acetyltransferase p300 (LOC446056), E1A binding protein p300 (ep300), E1A binding protein p300 (Ep300), A430090G16, A730011L11, KAT3B, p300, p300 HAT, RSTS2Protein level used designations for p300
- histone acetyltransferase p300
- histone acetyltransferase
- E1A binding protein p300
- histone acetyltransferase p300-like
- E1A-associated protein p300
- E1A-binding protein, 300kD
- p300 HAT
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