p21 抗体
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010].
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Popular p21 抗体
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Human
Application
WB, IF
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Cat. No.
ABIN3022006
Quantity
100 μL
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Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (2)
- (5)
Cat. No.
ABIN560309
Quantity
100 μg
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Datasheet
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Application
WB, IHC
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- (7)
Cat. No.
ABIN7266599
Quantity
100 μL
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Datasheet
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Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7439048
Quantity
100 μL
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Application
WB, IHC (f)
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- (5)
Cat. No.
ABIN7504137
Quantity
100 μg
Datasheet
Datasheet
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Human, Non-Human Primate
Application
ELISA, IHC (p), ICC
Validations
- (2)
- (4)
Cat. No.
ABIN94444
Quantity
0.1 mg
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Datasheet
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Human, Mouse, Rat, Sheep
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WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
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- (2)
- (3)
Cat. No.
ABIN1714474
Quantity
100 μL
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Datasheet
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WB, IHC, IF, IHC (f)
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- (4)
Cat. No.
ABIN6939037
Quantity
100 μg
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Datasheet
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Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
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- (4)
Cat. No.
ABIN6256478
Quantity
100 μL
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Datasheet
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Human
Application
WB, ELISA, IHC, DB
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- (5)
Cat. No.
ABIN3031122
Quantity
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Datasheet
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Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7148907
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (3)
- (2)
Cat. No.
ABIN6263942
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (f)
Validations
- (3)
Cat. No.
ABIN6939042
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (f)
Validations
- (3)
Cat. No.
ABIN6939040
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC (f)
Validations
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Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our p21 抗体
: "Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease." in: American journal of respiratory cell and molecular biology, (2021) (PubMed).: "Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A." in: Molecular medicine reports, Vol. 22, Issue 5, pp. 3873-3885, (2021) (PubMed).
: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).
: "Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells." in: Cell biology and toxicology, (2019) (PubMed).
: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).
: "LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells." in: Gene, (2018) (PubMed).
: "Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells." in: Cell death & disease, Vol. 9, Issue 5, pp. 512, (2018) (PubMed).
: "Cullin3/KCTD5 induces monoubiquitination of ΔNp63α and impairs its activity." in: FEBS letters, Vol. 592, Issue 13, pp. 2334-2340, (2018) (PubMed).
: "Radiation-induced premature cellular senescence involved in glomerular diseases in rats." in: Scientific reports, Vol. 8, Issue 1, pp. 16812, (2018) (PubMed).
: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).
Aliases for p21 抗体
cyclin D1 (CCND1) 抗体cyclin dependent kinase inhibitor 1A (CDKN1A) 抗体
cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a) 抗体
cyclin-dependent kinase inhibitor 1A (Cdkn1a) 抗体
cyclin-dependent kinase inhibitor 1A L homeolog (cdkn1a.L) 抗体
cyclin-dependent kinase inhibitor 1 (cki1) 抗体
cyclin-dependent kinase inhibitor 1A (cdkn1a) 抗体
cyclin dependent kinase inhibitor 1A (Cdkn1a) 抗体
KRAS proto-oncogene, GTPase (KRAS) 抗体
CAP20 抗体
cap20 抗体
CCND1 抗体
CDKI 抗体
CDKN1 抗体
Cdkn1 抗体
cdkn1 抗体
CDKN1A 抗体
CIP1 抗体
Cip1 抗体
cip1 抗体
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mda-6 抗体
mda6 抗体
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P21 抗体
p21 抗体
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p21Cip1 抗体
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sdi1 抗体
si:ch1073-48m5.2 抗体
UV96 抗体
WAF1 抗体
Waf1 抗体
waf1 抗体
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