p130 抗体
(Retinoblastoma-Like 2 (p130) (RBL2))
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Popular p130 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542553
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, FACS
Validations
- (1)
- (3)
Cat. No.
ABIN656158
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IF, IHC
Validations
- (2)
Cat. No.
ABIN7075406
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF, IHC, IHC (p), IP
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- (2)
Cat. No.
ABIN1491690
Quantity
250 μL
Datasheet
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Reactivity
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Application
WB, IF
Validations
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Cat. No.
ABIN7269943
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
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Cat. No.
ABIN7167791
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
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Cat. No.
ABIN6241739
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
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Cat. No.
ABIN7247960
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
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Cat. No.
ABIN562603
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
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Cat. No.
ABIN519666
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN6264666
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (1)
Cat. No.
ABIN1103924
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Chimpanzee
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN349607
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (2)
Cat. No.
ABIN2780695
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
Cat. No.
ABIN1714570
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our p130 抗体
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." in: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).
: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." in: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).
: "Frequent loss of pRb2/p130 in human ovarian carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).
: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).
: "The retinoblastoma family: twins or distant cousins?" in: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).
: "p107 and p130: versatile proteins with interesting pockets." in: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).
: "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19." in: Oncogene, Vol. 8, Issue 12, pp. 3465-8, (1993) (PubMed).
Aliases for p130 抗体
retinoblastoma-like 2 (p130) (RBL2) 抗体RB transcriptional corepressor like 2 (RBL2) 抗体
related to retinoblastoma 2 (LOC541652) 抗体
RB transcriptional corepressor like 2 (Rbl2) 抗体
p130 抗体
P130 抗体
PRB2 抗体
Rb2 抗体
RBL2 抗体
RBR-2 抗体
RBR2 抗体
RRB2a 抗体
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