(Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008].
Katakai, Mori, Masuda, Shimizu: "Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or alpha(4)beta(7)-integrin at the lesions of autoimmune gastritis." in: International immunology, Vol. 14, Issue 2, pp. 167-75, (2002) (PubMed).
Austrup, Vestweber, Borges, Löhning, Bräuer, Herz, Renz, Hallmann, Scheffold, Radbruch, Hamann: "P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues." in: Nature, Vol. 385, Issue 6611, pp. 81-3, (1997) (PubMed).
Lenter, Levinovitz, Isenmann, Vestweber: "Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells." in: The Journal of cell biology, Vol. 125, Issue 2, pp. 471-81, (1994) (PubMed).
Hahne, Jäger, Isenmann, Hallmann, Vestweber: "Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes." in: The Journal of cell biology, Vol. 121, Issue 3, pp. 655-64, (1993) (PubMed).