PAX5 产品
(Paired Box 5 (PAX5))
Categories
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Featured PAX5 Categories
PAX5 抗体
High quality antibodies with extensive validation data.
PAX5 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PAX5 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PAX5 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), RNAi
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- (6)
Cat. No.
ABIN562112
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC, StM
Validations
- (5)
Cat. No.
ABIN6940256
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
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- (2)
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Cat. No.
ABIN1098104
Quantity
100 μL
Datasheet
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Recommended PAX5 ELISA试剂盒
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Human, Mouse
Analytical Method
Qualitative Cell ELISA
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Cat. No.
ABIN1381403
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5661953
Quantity
96 tests
Datasheet
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Recommended PAX5 蛋白
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Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124296
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314073
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314071
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PAX5 Products
: "Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report." in: Experimental and therapeutic medicine, Vol. 16, Issue 3, pp. 2060-2065, (2018) (PubMed).: "PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene." in: Gene, Vol. 555, Issue 2, pp. 194-202, (2014) (PubMed).
: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." in: Cancer research, Vol. 71, Issue 24, pp. 7345-50, (2011) (PubMed).
: "The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 455-67, (2011) (PubMed).
: "Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." in: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).
: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." in: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, (2009) (PubMed).
: "Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells." in: British journal of haematology, Vol. 147, Issue 3, pp. 328-38, (2009) (PubMed).
: "Transcriptional analysis of the B cell germinal center reaction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2639-44, (2003) (PubMed).
: "Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma." in: Oncogene, Vol. 21, Issue 32, pp. 4908-20, (2002) (PubMed).
: "Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin." in: Blood, Vol. 94, Issue 9, pp. 3108-13, (1999) (PubMed).
Synonyms and alternative names related to PAX5
paired box 5 (PAX5), paired box 5 L homeolog (pax5.L), paired box 5 (Pax5), paired box 5 (pax5), BSAP, EBB-1, KLP, noi, Pax-5, pax2.1, pax2a, PAX5, pax5-a, paxzf-b, Pax[Zf-b], RGD1565236Protein level used designations for PAX5
- paired box 5
- paired box gene 5 (B-cell lineage specific activator)
- paired box protein Pax-5
- paired box protein Pax-5-like
- B-cell lineage specific activator
- paired box homeotic gene 5
- paired domain gene 5
- transcription factor PAX 5
- XPax-5
- B-cell-specific transcription factor
- Pax5 variant 1
- Pax5 variant 2
- No isthmus protein
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