PARL 产品
(Presenilin Associated, Rhomboid-Like (PARL))
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This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured PARL Categories
Recommended PARL 抗体
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Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (1)
- (5)
Cat. No.
ABIN2782038
Quantity
100 μL
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Dog, Human, Mouse, Rat
Application
WB, IHC
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- (3)
Cat. No.
ABIN634971
Quantity
100 μL
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Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7164273
Quantity
100 μL
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Recommended PARL 蛋白
Latest Publications for our PARL Products
: "The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 11, pp. 1658-65, (2013) (PubMed).: "Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons." in: Nature, Vol. 452, Issue 7183, pp. 98-102, (2008) (PubMed).
: "Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling." in: Cell, Vol. 126, Issue 1, pp. 163-75, (2006) (PubMed).
: "Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18562-7, (2006) (PubMed).
: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." in: Nature, Vol. 423, Issue 6939, pp. 537-41, (2003) (PubMed).
: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." in: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, (2002) (PubMed).
Synonyms and alternative names related to PARL
presenilin associated rhomboid like (PARL), presenilin associated, rhomboid-like (Parl), presenilin associated rhomboid like (Parl), presenilin associated, rhomboid-like a (parla), D16Ertd607e, parl, PRO2207, PSARL, Psarl, PSARL1, PSENIP2, RHBDS1, zgc:112986Protein level used designations for PARL
- mitochondrial intramembrane cleaving protease PARL
- mitochondrial intramembrane-cleaving protease PARL
- presenilins-associated rhomboid-like protein, mitochondrial
- rhomboid 7 homolog 1
- presenilin associated, rhomboid-like isoform 1 preproprotein
- presenilin associated, rhomboid-like preproprotein
- parlb
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