ORC1 产品
(Origin Recognition Complex, Subunit 1 (ORC1L))
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The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
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Featured ORC1 Categories
Recommended ORC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7252684
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (1)
- (1)
Cat. No.
ABIN108601
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC (p)
Validations
- (2)
Cat. No.
ABIN518535
Quantity
100 μg
Datasheet
Datasheet
Recommended ORC1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313648
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094294
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137604
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ORC1 Products
: "SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation." in: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6306-16, (2013) (PubMed).: "The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication." in: Journal of cell science, Vol. 123, Issue Pt 16, pp. 2743-9, (2010) (PubMed).
: "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1." in: The Journal of biological chemistry, Vol. 276, Issue 18, pp. 15397-408, (2001) (PubMed).
: "Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus." in: The EMBO journal, Vol. 20, Issue 16, pp. 4588-602, (2001) (PubMed).
Synonyms and alternative names related to ORC1
Origin recognition complex subunit 1 (Orc1), origin recognition complex subunit 1 (Orc1), origin recognition complex subunit 1 (ORC1), origin recognition complex subunit 1 L homeolog (orc1.L), origin recognition complex, subunit 1 (Orc1), AA545195, CG10667, Dmel\\CG10667, DmORC1, DmOrc1, DmOrc1p, dORC1, HSORC1, MmORC1, ORC, ORC1, orc1, ORC1L, orc1l, Orc1l, PARC1, rDmORC, xorc1Protein level used designations for ORC1
- CG10667-PA
- Orc1-PA
- origin recognition complex 1
- origin recognition complex subunit 1
- origin recognition complex, subunit 1 homolog
- replication control protein 1
- origin recognition complex protein 1
- origin recognition complex, subunit 1-like
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