OGG1 产品
(8-Oxoguanine DNA Glycosylase (OGG1))
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This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].
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Featured OGG1 Categories
OGG1 抗体
High quality antibodies with extensive validation data.
OGG1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
OGG1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended OGG1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, IHC, ELISA, IP, ICC, IF
Validations
- (7)
Cat. No.
ABIN363384
Quantity
0.1 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7435088
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN702655
Quantity
100 μL
Datasheet
Datasheet
Recommended OGG1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953379
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964509
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964508
Quantity
96 tests
Datasheet
Datasheet
Recommended OGG1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667178
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121628
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313352
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our OGG1 Products
: "Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats." in: The Journal of physiology, Vol. 597, Issue 9, pp. 2391-2401, (2019) (PubMed).: "Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 6, pp. 7758-7766, (2019) (PubMed).
: "Levels of oxidative DNA damage are low in ex vivo engineered human limbal epithelial tissue." in: Acta ophthalmologica, Vol. 96, Issue 8, pp. 834-840, (2019) (PubMed).
: "Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis." in: Molecular cell, Vol. 75, Issue 1, pp. 117-130.e6, (2019) (PubMed).
: "Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels." in: Oxidative medicine and cellular longevity, Vol. 2018, pp. 6956414, (2018) (PubMed).
: "CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells." in: Nutrients, Vol. 10, Issue 7, (2018) (PubMed).
: "Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis." in: Oncology letters, Vol. 16, Issue 2, pp. 1765-1776, (2018) (PubMed).
: "The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities." in: PLoS ONE, Vol. 12, Issue 1, pp. e0164281, (2017) (PubMed).
: "Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice." in: Oncotarget, Vol. 8, Issue 21, pp. 34082-34098, (2017) (PubMed).
: "The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription." in: Nucleic acids research, Vol. 46, Issue 2, pp. 661-676, (2017) (PubMed).
Synonyms and alternative names related to OGG1
8-oxoguanine DNA glycosylase (OGG1), 8-oxoguanine DNA glycosylase L homeolog (ogg1.L), 8-oxoguanine DNA glycosylase (ogg1), 8-oxoguanine-DNA glycosylase 1 (OGG1), 8-OXOGUANINE DNA GLYCOSYLASE (ECU08_0770), 8-oxoguanine DNA glycosylase (CA_C2707), 8-oxoguanine DNA glycosylase (BBOV_I004290), putative 8-oxoguanine DNA glycosylase (Smp_074010.1), 8-oxoguanine DNA-glycosylase (ogg1), N-glycosylase/DNA lyase OGG1 (LOC9329243), 8-oxoguanine DNA glycosylase (Tb927.4.2480), 8-oxoguanine DNA glycosylase (Ogg1), 8-oxoguanine DNA-glycosylase 1 (Ogg1), 8-oxoguanine-DNA glycosylase 1, 19.m02329, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1, ATOGG1, DDBDRAFT_0184479, DDBDRAFT_0233024, DDB_0184479, DDB_0233024, F8K7.14, F8K7_14, HMMH, HOGG1, Mmh, MUTM, OGG1, ogg1, OGH1, Tb04.1H19.930, zgc:158858Protein level used designations for OGG1
- 8-oxoguanine DNA glycosylase
- N-glycosylase/DNA lyase
- 8-OXOGUANINE DNA GLYCOSYLASE
- 8-oxoguanine-DNA-glycosylase
- DNA-formamidopyrimidine glycosylase
- 8-oxoguanine-DNA glycosylase 1
- 8-oxoguanine DNA-glycosylase 1
- n-glycosylase/DNA lyase-like
- 8-hydroxyguanine DNA glycosylase
- AP lyase
- DNA-apurinic or apyrimidinic site lyase
- OGG1 type 1f
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