OAS1 产品
(2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
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This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured OAS1 Categories
OAS1 抗体
High quality antibodies with extensive validation data.
OAS1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
OAS1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended OAS1 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
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- (8)
Cat. No.
ABIN7435079
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7435082
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (7)
- (3)
Cat. No.
ABIN390164
Quantity
400 μL
Datasheet
Datasheet
Recommended OAS1 ELISA试剂盒
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Reactivity
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Pig
Analytical Method
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Cat. No.
ABIN1118759
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5593383
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5651266
Quantity
96 tests
Datasheet
Datasheet
Recommended OAS1 蛋白
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1313295
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121603
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
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Cat. No.
ABIN1313297
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our OAS1 Products
: "Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells." in: Immunology and cell biology, Vol. 92, Issue 2, pp. 105-15, (2014) (PubMed).: "RIG-I-like receptors mediate innate antiviral response in mouse testis." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 9, pp. 1455-67, (2013) (PubMed).
: "The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization." in: Lung cancer (Amsterdam, Netherlands), Vol. 78, Issue 1, pp. 30-8, (2012) (PubMed).
: "Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway." in: Cancer research, Vol. 71, Issue 1, pp. 255-65, (2011) (PubMed).
: "Azithromycin induces anti-viral responses in bronchial epithelial cells." in: The European respiratory journal, Vol. 36, Issue 3, pp. 646-54, (2010) (PubMed).
: "The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28343-51, (2009) (PubMed).
: "Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15845-52, (2008) (PubMed).
: "IFI16 in human prostate cancer." in: Molecular cancer research : MCR, Vol. 5, Issue 3, pp. 251-9, (2007) (PubMed).
: "A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L." in: Journal of virology, Vol. 81, Issue 11, pp. 5561-72, (2007) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
Synonyms and alternative names related to OAS1
2',5'-oligoadenylate synthetase 1 (OAS1), 2'-5'-oligoadenylate synthetase 1 (OAS1), 2'-5' oligoadenylate synthetase 1A (Oas1a), protein phosphatase 2 catalytic subunit beta (Ppp2cb), 2'-5'-oligoadenylate synthetase 1 (Oas1), IFI-4, L3, OAS1, OIAS, OIASI, Pp2a2Protein level used designations for OAS1
- 2',5'-oligoadenylate synthetase 1
- 2',5'-oligoadenylate synthetase 1, 40/46kDa
- 2'-5'-oligoadenylate synthase 1
- (2-5')oligo(A) synthase 1
- (2-5')oligo(A) synthetase 1
- 2'-5' oligoadenylate synthetase
- 2-5A synthase 1
- 2-5A synthetase 1
- p42 OAS
- 2-5-oligoadenylate synthetase 1
- 2'-5' oligoadenylate synthetase 1
- 2',5'-oligo A synthetase 1
- 2'-5' oligoadenylate synthetase 1 p48 isoform
- 2'-5' oligoadenylate synthetase 1 p52 isoform
- 2'-5'-oligoisoadenylate synthetase 1
- E18/E16
- p46/p42 OAS
- 2'-5'-oligoadenylate synthetase 1-like
- 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- (2-5')oligo(A) synthase 1A
- (2-5')oligo(A) synthetase 1A
- 2'-5'-oligoadenylate synthase 1A
- 2-5A synthase 1A
- 2-5A synthetase 1A
- PP2A-beta
- protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
- protein phosphatase 2, catalytic subunit, beta isoform
- protein phosphatase 2A catalytic alpha subunit
- protein phosphatase 2a, catalytic subunit, beta isoform
- protein phosphatase-2A-beta
- serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1
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