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NUB1 产品

(Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

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This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].

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Featured NUB1 Categories

NUB1 抗体

High quality antibodies with extensive validation data.

NUB1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NUB1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Human, Monkey, Rat
Application WB, IHC, IHC (p), IF, FACS
Validations
  • (7)
Cat. No. ABIN1490743
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse
Application WB, IHC, ELISA, IF, ICC
Validations
  • (4)
Cat. No. ABIN6263785
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p), FACS
Validations
  • (4)
Cat. No. ABIN1490744
Quantity 100 μL
Datasheet Datasheet

Recommended NUB1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381369
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1144444
Quantity 96 tests
Datasheet Datasheet

Recommended NUB1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313139
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313137
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3084737
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our NUB1 Products

Tanaka, Kawashima, Yeh, Kamitani: "Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 32905-13, (2003) (PubMed).

Akey, Zhu, Dyer, Li, Sorensen, Blackshaw, Fukuda-Kamitani, Daiger, Craft, Kamitani, Sohocki: "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1." in: Human molecular genetics, Vol. 11, Issue 22, pp. 2723-33, (2002) (PubMed).

Kito, Yeh, Kamitani: "NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 20603-9, (2001) (PubMed).

Synonyms and alternative names related to NUB1

negative regulator of ubiquitin-like proteins 1 (Nub1), negative regulator of ubiquitin like proteins 1 (NUB1), 4931404D21Rik, 6330412F12Rik, BS4, NUB1L, NY-REN-18, NYREN18

Protein level used designations for NUB1

  • NEDD8 ultimate buster 1
  • NEDD8 ultimate buster-1
  • NY-REN-18 antigen
  • renal carcinoma antigen NY-REN-18
  • Nedd8 ultimate buster-1
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