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NR1I3 产品

(Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

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This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured NR1I3 Categories

NR1I3 抗体

High quality antibodies with extensive validation data.

NR1I3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

NR1I3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NR1I3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (5)
Cat. No. ABIN7259546
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7161898
Quantity 100 μg
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN462245
Quantity 50 μg
Datasheet Datasheet

Recommended NR1I3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969015
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969014
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969016
Quantity 96 tests
Datasheet Datasheet

Recommended NR1I3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312943
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312942
Quantity 25 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418869
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NR1I3 Products

Sharma, Lau, Sherman, Chang: "Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine." in: British journal of pharmacology, Vol. 172, Issue 5, pp. 1263-76, (2015) (PubMed).

Synonyms and alternative names related to NR1I3

nuclear receptor subfamily 1 group I member 3 (NR1I3), nuclear receptor subfamily 1, group I, member 3 (Nr1i3), AA209988, AI551208, CAR, CAR-beta, CAR1, Care2, CXR, ESTM32, MB67

Protein level used designations for NR1I3

  • constitutive androstane receptor
  • constitutively transactivates RAREs
  • nuclear receptor subfamily 1 group I member 3
  • orphan nuclear receptor MB67
  • constitutive androstane receptor NR1I3
  • nuclear receptor constitutive active receptor
  • strain Fischer nuclear receptor (CAR)
  • constitutive activator of retinoid response
  • constitutive active receptor
  • constitutive active response
  • constitutive androstane nuclear receptor variant 2
  • constitutive androstane nuclear receptor variant 3
  • constitutive androstane nuclear receptor variant 4
  • constitutive androstane nuclear receptor variant 5
  • orphan nuclear hormone receptor
  • xenobiotic receptor
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