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NR1H3 产品

(Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))

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The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Featured NR1H3 Categories

NR1H3 抗体

High quality antibodies with extensive validation data.

NR1H3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

NR1H3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NR1H3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p)
Validations
  • (7)
Cat. No. ABIN7217836
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (3)
Cat. No. ABIN523441
Quantity 100 μg
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (4)
Cat. No. ABIN462212
Quantity 50 μg
Datasheet Datasheet

Recommended NR1H3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958254
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969010
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958253
Quantity 96 tests
Datasheet Datasheet

Recommended NR1H3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312934
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2727545
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395752
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NR1H3 Products

Sun, Tang, Hou, Wang, Huang, Wen, Niu, Zeng, Bai: "Novel Lactobacillus reuteri HI120 Affects Lipid Metabolism in C57BL/6 Obese Mice." in: Frontiers in veterinary science, Vol. 7, pp. 560241, (2020) (PubMed).

Torres-Luquis, Madden, Ndri, Berg, Olopade, Ngwa, Abuidris, Mittal, Lyn-Cook, Mohammed: "LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women." in: Breast cancer (Dove Medical Press), Vol. 11, pp. 1-12, (2019) (PubMed).

Bruschi, Claudel, Tardelli, Starlinger, Marra, Trauner: "PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells." in: Hepatology communications, Vol. 3, Issue 9, pp. 1191-1204, (2019) (PubMed).

Ahn, Jun, Jang, Lee, Shin: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).

Qian, Ma, Wu, Yu, Lin, Ying, Wen, Gao: "G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice." in: Vascular pharmacology, Vol. 89, pp. 49-57, (2017) (PubMed).

Tian, Goldstein, Brown: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).

Kemmerer, Wittig, Richter, Brüne, Namgaladze: "AMPK activates LXRα and ABCA1 expression in human macrophages." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 1-9, (2016) (PubMed).

Schmitt, Kong, Stieger, Tschopp, Schultze, Rau, Weber, Müllhaupt, Guo, Geier: "Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 35, Issue 4, pp. 1133-44, (2015) (PubMed).

Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: "Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 503-8, (2014) (PubMed).

Ahn, Jang, Jun, Lee, Shin: "Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease." in: Digestive diseases and sciences, Vol. 59, Issue 12, pp. 2975-82, (2014) (PubMed).

Synonyms and alternative names related to NR1H3

nuclear receptor subfamily 1 group H member 3 (NR1H3), nuclear receptor subfamily 1 group H member 3 (nr1h3), nuclear receptor subfamily 1, group H, member 3 (Nr1h3), nuclear receptor subfamily 1, group H, member 3 (nr1h3), AU018371, im:7141239, LXR, LXR-a, LXR-alpha, LXRA, LXRalpha, NR1H3, RLD-1, RLD1, Unr1, wu:fd59b01, zgc:113339, zgc:158542

Protein level used designations for NR1H3

  • nuclear receptor subfamily 1, group H, member 3
  • oxysterols receptor LXR-alpha-like
  • liver X nuclear receptor alpha variant 1
  • oxysterols receptor LXR-alpha
  • LXR alpha
  • liver X receptor alpha
  • ubiquitously-expressed nuclear receptor 1
  • nuclear orphan receptor LXR-alpha
  • nuclear receptor subfamily 1 group H member 3
  • LXRalpha
  • liver X receptor
  • lxr
  • nuclear oxysterol receptor LxR-alpha
  • RLD-1
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