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NPC1L1 抗体

(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
NPC1L1 抗体  (N-Term) NPC1L1 抗体  (N-Term) NPC1L1 抗体 (N-Term) (ABIN1881583)

NPC1L1 适用: 人 WB 宿主: 兔 Polyclonal RB42754 unconjugated

NPC1L1 抗体  (Internal Region) NPC1L1 抗体  (Internal Region) NPC1L1 抗体 (Internal Region) (ABIN1804672)

NPC1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

Recombinant NPC1L1 抗体 Recombinant NPC1L1 抗体 Recombinant NPC1L1 抗体 (ABIN7127645)

NPC1L1 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 4B10 unconjugated Recombinant Antibody

NPC1L1 抗体 by Grade

Find NPC1L1 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

NPC1L1 抗体 by 适用

Find NPC1L1 抗体 for a variety of species such as anti-Human NPC1L1, anti-Mouse NPC1L1, anti-Rat NPC1L1. The species listed below are among those available. Click on a link to go to the corresponding products.

NPC1L1 抗体 by 应用范围

Find NPC1L1 抗体 validated for a specific application such as WB, ELISA, IHC, ICC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

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NPC1L1 抗体 by 抗原表位

Find NPC1L1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

NPC1L1 抗体 by 克隆形成能力

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NPC1L1 抗体 by 克隆

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NPC1L1 抗体 by 标记

Find NPC1L1 抗体 with a specific conjugate such as APC, Biotin, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular NPC1L1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (5)
  • (1)
Cat. No. ABIN1881583
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN1804672
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7127645
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN791336
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, ICC, IF
Validations
  • (1)
Cat. No. ABIN6263697
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6144760
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA
Validations
Cat. No. ABIN768613
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application ELISA
Validations
Cat. No. ABIN768614
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN1807106
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
Cat. No. ABIN596791
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN1918111
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN1918112
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN1918113
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN6864380
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN6840190
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our NPC1L1 抗体

Ontawong, Duangjai, Muanprasat, Pasachan, Pongchaidecha, Amornlerdpison, Srimaroeng: "Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 52, pp. 187-197, (2019) (PubMed).

Meng, Gwag, Sui, Park, Zhou, Zhou: "The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling." in: JCI insight, Vol. 4, Issue 3, (2019) (PubMed).

Yamamoto, Yamanashi, Takada, Mu, Tanaka, Komine, Suzuki: "Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice." in: Molecular pharmacology, Vol. 96, Issue 1, pp. 47-55, (2019) (PubMed).

Nihei, Nagafuku, Hayamizu, Odagiri, Tamura, Kikuchi, Veillon, Kanoh, Inamori, Arai, Kabayama, Fukase, Inokuchi: "NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains." in: Journal of lipid research, Vol. 59, Issue 11, pp. 2181-2187, (2018) (PubMed).

Ahn, Jun, Jang, Lee, Shin: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).

Soayfane, Tercé, Cantiello, Robenek, Nauze, Bézirard, Allart, Payré, Capilla, Cartier, Peres, Al Saati, Théodorou, Nelson, Yen, Collet, Coméra: "Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane." in: Nutrition & metabolism, Vol. 13, pp. 48, (2016) (PubMed).

Kikuchi, Orihara, Oikawa, Han, Kuba, Okuda, Satoh, Osaki, Takeuchi, Aita, Matsuzaka, Iwasaki, Yatoh, Sekiya, Yahagi, Suzuki, Sone, Nakagawa, Yamada, Shimano: "Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression." in: Molecular metabolism, Vol. 5, Issue 11, pp. 1092-1102, (2016) (PubMed).

Sachdev, Leopold, Bauer, Patankar, Iqbal, Obrowsky, Boverhof, Doktorova, Scheicher, Goeritzer, Kolb, Turnbull, Zimmer, Hoefler, Hussain, Groen, Kratky: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).

Feng, Zou, Zhang, Li, Lu: "Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters." in: Journal of agricultural and food chemistry, Vol. 65, Issue 2, pp. 276-280, (2016) (PubMed).

Takada, Yamanashi, Konishi, Yamamoto, Toyoda, Masuo, Yamamoto, Suzuki: "NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy." in: Science translational medicine, Vol. 7, Issue 275, pp. 275ra23, (2015) (PubMed).

Aliases for NPC1L1 抗体

NPC1 like intracellular cholesterol transporter 1 (NPC1L1) 抗体
NPC1 like 1 (npc1l1) 抗体
NPC1-like 1 (npc1l1) 抗体
NPC1 like intracellular cholesterol transporter 1 (Npc1l1) 抗体
9130221N23Rik 抗体
Gm243 抗体
NPC1L1 抗体
NPC11L1 抗体
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