NPC1L1 产品
(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
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The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Recommended NPC1L1 抗体
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Reactivity
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Datasheet
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Application
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Cat. No.
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Quantity
400 μL
Datasheet
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Application
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Cat. No.
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Recommended NPC1L1 蛋白
Latest Publications for our NPC1L1 Products
: "Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 52, pp. 187-197, (2019) (PubMed).: "The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling." in: JCI insight, Vol. 4, Issue 3, (2019) (PubMed).
: "Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice." in: Molecular pharmacology, Vol. 96, Issue 1, pp. 47-55, (2019) (PubMed).
: "NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains." in: Journal of lipid research, Vol. 59, Issue 11, pp. 2181-2187, (2018) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).
: "Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane." in: Nutrition & metabolism, Vol. 13, pp. 48, (2016) (PubMed).
: "Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression." in: Molecular metabolism, Vol. 5, Issue 11, pp. 1092-1102, (2016) (PubMed).
: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).
: "Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters." in: Journal of agricultural and food chemistry, Vol. 65, Issue 2, pp. 276-280, (2016) (PubMed).
: "NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy." in: Science translational medicine, Vol. 7, Issue 275, pp. 275ra23, (2015) (PubMed).
Synonyms and alternative names related to NPC1L1
NPC1 like intracellular cholesterol transporter 1 (NPC1L1), NPC1 like 1 (npc1l1), NPC1-like 1 (npc1l1), NPC1 like intracellular cholesterol transporter 1 (Npc1l1), 9130221N23Rik, Gm243, NPC1L1, NPC11L1Protein level used designations for NPC1L1
- NPC1-like 1
- NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- Niemann-Pick C1-like protein 1
- Niemann-Pick C1-like 1 protein
- Niemann-Pick C1-like protein 1-like
- Niemann-Pick disease, type C1
- Niemann-Pick disease, type C1-like 1
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