Notch Signaling
高度保守的Notch信号通路是独一无二的，因为Notch受体及其大多数相应配体（公认的DSL或Delta/Serrate/LAG-2 DSL家族成员）都是附着在细胞表面的跨膜蛋白。因此，Notch信号对相邻细胞之间的相互作用是有限的。
相邻细胞之间的通信至关重要，特别是在细胞的命运和功能尚未确定的早期发展阶段。Notch信号为细胞提供了一种指定自己身份的方法，同时通过侧抑制作用影响相邻细胞的角色和身份。 Notch信号通路的核心包括两个相邻细胞，一个表达DSL家族配体，另一个表达Notch（受体）。当受体与配体相互作用时，两个独立的蛋白酶把North分成为胞外和胞质两部分。ADAM10裂解与其各自配体结合的North余体胞外部分，并被表达细胞的配体吞噬。γ-分泌酶裂解Notch胞质部分。胞质区迁移到细胞核，并在这里与转录因子CSL结合，将其从一个转录阻遏物转化成一个激活物，并上调Notch靶基因的表达。
Notch
NOTCH1 - Notch1:
NOTCH2 (Notch 2):
NOTCH3 (Notch 3):
NOTCH4 (Notch 4):
Notch Antagonists
AP2A1 - alpha Adaptin:
FBXW7 (F-Box and WD Repeat Domain Containing 7):
NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase):
SGK1 (serum/glucocorticoid Regulated Kinase 1):
Notch Ligands
DLL1 (delta-Like 1):
JAG1 (Jagged 1):
DLL3 (delta Like Protein 3):
DLL4 (delta-Like 4):
JAG2 (Jagged 2):
Notch Processing
FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)):
LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):
MFNG - Manic Fringe:
POFUT1 (Protein O-Fucosyltransferase 1):
POGLUT1 (Protein O-Glucosyltransferase 1):
RFNG (RFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):
Notch Directed Proteases
ADAM10 (ADAM Metallopeptidase Domain 10):
APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans)):
ADAM17 (ADAM Metallopeptidase Domain 17):
NCSTN - Nicastrin:
PSEN1 - Presenilin 1:
PSEN2 - Presenilin 2:
PSENEN - PEN2:
Pathway Agonists
DTX1 - Deltex Homolog 1:
NEURL1B (Neuralized E3 Ubiquitin Protein Ligase 1B):
CRB2 (Crumbs Homolog 2):
CRB3 (Crumbs Homolog 3):
DTX3 - Deltex Homolog 3:
DTX4 - Deltex Homolog 4:
MIB2 (E3 ubiquitin-protein ligase MIB2):
NEURL (Neuralized Homolog (Drosophila)):
Transcription Factors
KCNJ5 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5):
NCOR2 (Nuclear Receptor Co-Repressor 2):
EP300 - p300:
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