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NOG 蛋白

(Noggin (NOG))
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
NOG Protein (AA 20-232) NOG Protein (AA 20-232) NOG Protein (AA 20-232) (ABIN2018288)

NOG 宿主: 小鼠 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

NOG 蛋白 NOG 蛋白 NOG 蛋白 (ABIN7275358)

NOG 宿主: 人 宿主: CHO Cells Recombinant > 95% as determined by Tris-Bis PAGE

NOG Protein (AA 28-232) NOG Protein (AA 28-232) NOG Protein (AA 28-232) (ABIN2018291)

NOG 宿主: 人 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

NOG 蛋白 by Origin

Find NOG 蛋白 for a variety of species such as anti-Human NOG, anti-Mouse NOG, anti-Rat NOG. The species listed below are among those available. Click on a link to go to the corresponding products.

NOG 蛋白 by Source

Here you will find NOG 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

NOG 蛋白 by 蛋白类型

Here you can find NOG 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

NOG 蛋白 by 应用范围

Find NOG 蛋白 validated for a specific application such as WB, SDS, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

NOG 蛋白 by 生物活性

Find NOG 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular NOG 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source CHO Cells
Validations
  • (1)
  • (2)
Cat. No. ABIN2018288
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source CHO Cells
Validations
  • (2)
Cat. No. ABIN7275358
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source CHO Cells
Validations
  • (2)
Cat. No. ABIN2018291
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320797
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124188
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312765
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7455653
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2181545
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN5509401
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN5509402
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7504482
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7504483
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7504481
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395929
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN988177
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our NOG 蛋白

Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).

Guan, Du, Lv, Qu, Fu, Yuan et al.: "Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling ..." in: Clinical and experimental pharmacology & physiology, Vol. 43, Issue 1, pp. 125-34, (2016) (PubMed).

Ye, Ge, Zhang, Cheng, Zhang, He, Wang, Lin, Yang, Liu, Zhao, Deng: "Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds." in: Cell research, Vol. 26, Issue 1, pp. 34-45, (2016) (PubMed).

Miyagi, Mikawa, Sato, Hasegawa, Kobayashi, Matsuyama, Sato: "BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord." in: Neuroscience, Vol. 203, pp. 12-26, (2012) (PubMed).

Umezu, Yamanouchi, Iida, Miura, Tomooka: "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 10, pp. 4601-6, (2010) (PubMed).

Aliases for NOG 蛋白

noggin (NOG) 蛋白
noggin (Nog) 蛋白
noggin L homeolog (nog.L) 蛋白
noggin protein (noggin) 蛋白
nog-A 蛋白
nog1 蛋白
noggin 蛋白
noggin-1 蛋白
SYM1 蛋白
SYNS1 蛋白
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