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NOG 抗体

(Noggin (NOG))
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
NOG 抗体  (AA 28-232) NOG 抗体  (AA 28-232) NOG 抗体 (AA 28-232) (ABIN1491315)

NOG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C12 unconjugated

NOG 抗体  (AA 28-232) NOG 抗体  (AA 28-232) NOG 抗体 (AA 28-232) (ABIN7426478)

NOG 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal A7 unconjugated

NOG 抗体  (AA 28-232) NOG 抗体  (AA 28-232) NOG 抗体 (AA 28-232) (ABIN7434698)

NOG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

NOG 抗体 by 适用

Find NOG 抗体 for a variety of species such as anti-Human NOG, anti-Mouse NOG, anti-Rat NOG. The species listed below are among those available. Click on a link to go to the corresponding products.

NOG 抗体 by 应用范围

Find NOG 抗体 validated for a specific application such as WB, ELISA, IHC, FACS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

NOG 抗体 by 抗体来源

Find NOG 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

NOG 抗体 by 抗原表位

Find NOG 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

NOG 抗体 by 克隆形成能力

Find available monoclonal or polyclonal NOG 抗体. Click on a link to go to the corresponding products.

NOG 抗体 by 克隆

Find NOG 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

NOG 抗体 by 标记

Find NOG 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular NOG 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Human
Application WB, IHC, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN1491315
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7426478
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7434698
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (4)
Cat. No. ABIN522708
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (2)
Cat. No. ABIN873145
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7161677
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7244756
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (1)
Cat. No. ABIN7189467
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN522710
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN522711
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN522714
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN522707
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, ICC, IF
Validations
  • (1)
Cat. No. ABIN6263681
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1860019
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1860021
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our NOG 抗体

Song, Cui, Yu, Liu, Liu, Yang, He, Zhang: "Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin." in: General and comparative endocrinology, Vol. 260, pp. 18-24, (2017) (PubMed).

Choi, Stottmann, Yang, Meyers, Klingensmith: "The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis." in: Circulation research, Vol. 100, Issue 2, pp. 220-8, (2007) (PubMed).

Schwaninger, Rentsch, Wetterwald, van der Horst, van Bezooijen, van der Pluijm, Löwik, Ackermann, Pyerin, Hamdy, Thalmann, Cecchini: "Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases." in: The American journal of pathology, Vol. 170, Issue 1, pp. 160-75, (2007) (PubMed).

Groppe, Greenwald, Wiater, Rodriguez-Leon, Economides, Kwiatkowski, Affolter, Vale, Izpisua Belmonte, Choe: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, (2002) (PubMed).

Bachiller, Klingensmith, Kemp, Belo, Anderson, May, McMahon, McMahon, Harland, Rossant, De Robertis: "The organizer factors Chordin and Noggin are required for mouse forebrain development." in: Nature, Vol. 403, Issue 6770, pp. 658-61, (2000) (PubMed).

McMahon, Takada, Zimmerman, Fan, Harland, McMahon: "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite." in: Genes & development, Vol. 12, Issue 10, pp. 1438-52, (1998) (PubMed).

Valenzuela, Economides, Rojas, Lamb, Nuñez, Jones, Lp, Espinosa, Brannan, Gilbert: "Identification of mammalian noggin and its expression in the adult nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 9, pp. 6077-84, (1995) (PubMed).

Aliases for NOG 抗体

noggin (NOG) 抗体
noggin (Nog) 抗体
noggin L homeolog (nog.L) 抗体
noggin protein (noggin) 抗体
nog-A 抗体
nog1 抗体
noggin 抗体
noggin-1 抗体
SYM1 抗体
SYNS1 抗体
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