NOG 产品
(Noggin (NOG))
Categories
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
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Featured NOG Categories
NOG 抗体
High quality antibodies with extensive validation data.
NOG ELISA试剂盒
Reliable ELISA kits for a wide range of species.
NOG 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NOG 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1491315
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7426478
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7434698
Quantity
100 μL
Datasheet
Datasheet
Recommended NOG ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN6958214
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999472
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1145245
Quantity
96 tests
Datasheet
Datasheet
Recommended NOG 蛋白
Latest Publications for our NOG Products
: "Effects of material nano-topography on the angiogenesis of type H vessels: Size dependence, cell heterogeneity and intercellular communication." in: Biomaterials advances, Vol. 147, pp. 213307, (2023) (PubMed).: "Effect of tadalafil on penile nitric oxide synthase and corporal smooth muscle in rats under dutasteride treatment." in: The aging male : the official journal of the International Society for the Study of the Aging Male, Vol. 23, Issue 2, pp. 161-167, (2021) (PubMed).
: "Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 ..." in: Journal of cellular biochemistry, Vol. 120, Issue 9, pp. 14657-14669, (2020) (PubMed).
: "Effect of Simvastatin Use in Free Tissue Transfer: An Experimental Study in a Rat Epigastric Free Flap Model." in: Journal of reconstructive microsurgery, Vol. 36, Issue 4, pp. 281-288, (2020) (PubMed).
: "The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells." in: Biotechnology and applied biochemistry, Vol. 65, Issue 3, pp. 407-418, (2018) (PubMed).
: "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells." in: European cells & materials, Vol. 33, pp. 197-210, (2017) (PubMed).
: "Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin." in: General and comparative endocrinology, Vol. 260, pp. 18-24, (2017) (PubMed).
: "Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis." in: Heliyon, Vol. 3, Issue 11, pp. e00450, (2017) (PubMed).
: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).
: "Imbalance Between Bone Morphogenetic Protein 2 and Noggin Induces Abnormal Osteogenic Differentiation of Mesenchymal Stem Cells in Ankylosing Spondylitis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 2, pp. 430-40, (2016) (PubMed).
Synonyms and alternative names related to NOG
noggin (NOG), noggin (Nog), noggin L homeolog (nog.L), noggin protein (noggin), nog-A, nog1, noggin, noggin-1, SYM1, SYNS1Protein level used designations for NOG
- symphalangism 1 (proximal)
- noggin 1
- cNoggin
- noggin
- noggin protein
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